Programme

Download the complete agenda of the Mechanobiology of Cancer Summer School here

Schedule for the short talks sessions here

SEPTEMBER 17
17:00 – 18:30 Arrivals
18:30 – 20:00 Arrivals
20:00 – 21:00 Arrivals
21:00 – 22:00 Dinner

 

SEPTEMBER 18
09:00 – 09:45 Keynote Speaker: Guillaume SalbreuxPhysics of epithelial deformations
09:45 – 10:30
Leda Lacaria – Mechanical properties and structure of cortical cytoskeleton in micropatterned breast cancer cells
Yago Juste – The role of barotaxis in cancer cell migration
Jorge Barrasa – Enhancing the accuracy of 3D traction force microscopy by means of a physics-based inverse method
10:30 – 11:10 Coffee break
11:15 – 12:15
Ryan Murphy – An individual-based mechanical model of cell movement in heterogeneous tissues and its coarse-grained approximation
Julia Eckert – Approach to measure the Intracellular Stress of Cell-Cell Junctions
Sarah Boyle – Compressive forces in breast cancer activate RHO/ROCK-mediated cellular processes downstream of mechanosensitive ion channels
Pau Guillamat – Spiral and aster defects in monolayers of cells under confinement
12:15 – 13:00 Keynote Speaker: Buzz BaumCancer cell division
13:00 – 14:00 Lunch
14:00 – 14:30 Free time
14:30 – 16:30 2h walking trip
17:00 – 18:30 “Vertex modelling in biomechanics”Workshop organised by UPC
18:30 – 20:00 “Single molecule mechanics” Workshop organised by KCL
20:00 – 21:30 BBQ
21:30 – 22:00 Cremat

 

SEPTEMBER 19
09:00 – 09:45 Keynote Speaker: Marija PlodinecNanomechanical profiling of living epithelial tissues in health and disease and potential applications in routine clinical setting
09:45 – 10:30
Jennifer Young – Assaying ECM-conferred chemoresistance on orthogonal gradient hydrogel systems
Inés Velázquez-Quesada – Pranlukast antagonizes CD49f and reduces stemness in the MDA-MB-231 triple-negative breast cancer cell line
Isabelle Bourgot – Impact of cancer associated fibroblasts-derived cathepsin B on breast cancer progression
10:30 – 11:10 Coffee break
11:15 – 12:15
Karin Jansen – Basal-like breast cancer cells direct invasion by modulation of the extracellular matrix
Julian Eschenbruch – Cell force-mediated breast cancer invasion is attenuated by basement membrane integrity
Thomas Waring – Interrogation of acto-myosin mediated nuclear force coupling
Ignacio Viciano – Computational Modelling of the Cell Adhesive Interactions and Search of Small Molecule PPI Inhibitors as a Potential Cancer Drugs
12:15 – 13:00 Keynote Speaker: Peter FriedlPlasticity of adhesion and matrix guidance in cancer invasion and metastasis
13:00 – 14:00 Lunch
14:00 – 17:00 Free Time

Video shooting

17:00 – 18:30 “Traction force microscopy”  Workshop organised by IBEC
18:30 – 20:00 “Gel mechanics” Workshop organised by Noviocell
20:00 – 20:45 Free time
20:45 – 22:00 Dinner and Sky Watching

 

 

SEPTEMBER 20
09:00 – 09:45 Keynote Speaker: Andrew EwaldNovel roles of cell adhesion in breast cancer metastasis
09:45 – 10:30
Jenny Kechagia – The Integrin β4-keratin link impairs mechanosensing by protecting the nucleus form mechanical loading
Andrew Holle – Interplay between the nucleus and the cytoskeleton during self-directed breast cancer cell confined migration
Apeksha Shapeti – Quantifying 3D invasion and matrix deformations around CCM-2 depleted angiogenic sprouts highlights the role of mechanics in CCM
10:30 – 11:10 Coffee break
11:15 – 12:15
Magnus Bauer – Structural and mechanistic insights into mechanoactivation of Focal Adhesion Kinase
Lorna Young – Beta-pix and Myosin-18a are essential for adhesion-nucleus coupling required for breast cancer cell invasion
Santosh Phuyal – Spatiotemporal signalling of Rac1 at the endomembranes
Ariadna Marín – Linking epithelial size tension and pressure in curved epithelial monolayers
12:15 – 13:00 Keynote Speaker: Christina ScheelDynamic collagen deformation drives branching morphogenesis in mammary organoids derived from human breast tissue
13:00 – 14:00 Lunch
14:00 – 15:30 Free time
15:30 – 17:00 Poster Session
17:00 – 18:30 “Fundamentals of breast cancer biology” Workshop organised by UMCU
18:30 – 20:00 “Chemistry of tuneable gels” Workshop organised by INM
20:00 – 21:00 Free Time
21:00 – 22:00 Gala Dinner
22:30 – 01:30 Closing Celebration
SEPTEMBER 21
09:30 Departure