The MECHANO·CONTROL project is focused on the mechanical control of biological function. Mechanical forces transmitted through specific molecular bonds drive biological function, and their understanding and control hold an uncharted potential in oncology, regenerative medicine and biomaterial design.
MECHANO·CONTROL proposes to address this challenge by building an interdisciplinary research community with the aim of understanding and controlling cellular mechanics from the molecular to the organism scale.
At all stages and scales of the project, it will integrate experimental data with multi-scale computational modeling to establish the rules driving biological response to mechanics and adhesion. This approach aims to explore novel therapeutic approaches beyond the current paradigm in breast cancer treatment. If the partners can understand cancer biomechanics from the single molecule to the whole organ scale, they’ll be able to control mechanical forces to restore healthy cell behavior and inhibit tumor progression.
Beyond breast cancer, the general principles targeted by this technology will have high applicability in oncology, regenerative medicine, biomaterials, and many other biological processes and diseases.
MECHANO·CONTROL is a project funded by the European Commission, within the Future and Emerging Technologies (FET) proactive program.